The operation, part of the "Yuttha Bodin" mission, successfully targeted the Cambodian stronghold.
At 5.00pm, all four F-16s safely returned to base after completing the strike, the airforce said.
According to the Army Military Force Facebook page, at 4.40pm, Royal Thai Air Force F-16 fighter jets carried out an operation, "dropping eggs" (bombs) on a Cambodian military command post located south of the Prasat Ta Muen Thom temple.